ORGANIC AND INORGANIC SELENIUM SUPPLEMENTATION TO LACTATING MOTHERS INCREASE THE BLOOD AND MILK SE CONCENTRATIONS AND SE INTAKE BY BREAST-FED INFANTS

The aim of this study was to determine the effect of selenium (Se) sup plementation to lactating women on Se concentrations and glutathione p eroxidase (GSH-Px) activities in blood components of mothers and breas tfed infants and on milk Se levels and Se intake by breast-fed infants . Lactating mothers were supplied for 3 months with 200 mu g Se/day in the form of yeast-Se (Y-Se) and sodium selenite. Initial blood and pl asma Se levels of all women (n = 67) were 76.6 and 53.2 mu g/L, respec tively. After 3 months Se concentrations both in whole blood and in pl asma from mothers and infants were significantly higher than the initi al values. Y-Se exerts a stronger effect than selenite on blood and pl asma Se levels. Initial milk Se concentration was 8.9 mu g/L and after 1 month in both groups it reached a plateau at 14-16 mu g/L. This res ulted in an increase of Se intake in breast-fed infants from 6.1 to a plateau of 11-13 mu g Se/day. GSH-Px activities in plasma and red cell s of Y-Se group increased significantly and reached a plateau after 1 and 2 months, respectively, while in the selenite group the enzyme act ivities increased steadily throughout the entire period of the study. Selenite exerts a stronger effect on GSH-Px both in maternal and in in fant blood components as compared with Y-Se. In milk the GSH-Px activi ty in the Y-Se group did not change during the study, while in the sel enite group after 3 months it increased almost 2-fold compared to the initial value. In conclusion, this study shows that organic Se causes higher Se deposition than did the inorganic form.