U. Gubrelay et al., EFFECTS OF THIAMIN AND METHIONINE ADMINISTRATION IN PREVENTING CADMIUM-INDUCED BIOCHEMICAL-ALTERATIONS AND METAL CONCENTRATION IN MALE RATS, Journal of trace elements in medicine and biology, 12(2), 1998, pp. 86-90
Thiamin-or methionine supplementation was equally and moderately effec
tive in preventing the accumulation of cadmium in soft organs and alte
rations in a few selected biochemical indices during concomitant admin
istration. Adequate intake of sulfur amino acid following methionine s
upplementation might increase the bioavailability of glutathione, faci
litating the prevention of the binding of cadmium to different compart
ments and consequently reversing cadmium-induced biochemical disorders
. In the case of thiamine the possibility of formation of a readily ex
cretable complex between cadmium and thiamine or an increase in the bo
dy's resistance to cadmium might be the beneficial factor.