EFFECTS OF THIAMIN AND METHIONINE ADMINISTRATION IN PREVENTING CADMIUM-INDUCED BIOCHEMICAL-ALTERATIONS AND METAL CONCENTRATION IN MALE RATS

Thiamin-or methionine supplementation was equally and moderately effec tive in preventing the accumulation of cadmium in soft organs and alte rations in a few selected biochemical indices during concomitant admin istration. Adequate intake of sulfur amino acid following methionine s upplementation might increase the bioavailability of glutathione, faci litating the prevention of the binding of cadmium to different compart ments and consequently reversing cadmium-induced biochemical disorders . In the case of thiamine the possibility of formation of a readily ex cretable complex between cadmium and thiamine or an increase in the bo dy's resistance to cadmium might be the beneficial factor.