THE MACROPHAGE-INDUCED GENE MIG AS A MARKER FOR CLINICAL PATHOGENICITY AND IN-VITRO VIRULENCE OF MYCOBACTERIUM-AVIUM COMPLEX STRAINS

Authors
MEYER M VONGRUNBERG PWR KNOOP T HARTMANN P PLUM G
Citation
M. Meyer et al., THE MACROPHAGE-INDUCED GENE MIG AS A MARKER FOR CLINICAL PATHOGENICITY AND IN-VITRO VIRULENCE OF MYCOBACTERIUM-AVIUM COMPLEX STRAINS, Infection and immunity, 66(9), 1998, pp. 4549-4552
Citations number
15
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
66
Issue
9
Year of publication
1998
Pages
4549 - 4552
Database
ISI
SICI code
0019-9567(1998)66:9<4549:TMGMAA>2.0.ZU;2-H
Abstract
The capacity of 20 Mycobacterium avium complex isolates to multiply in tracellularly in human monocyte-derived macrophages was assessed and c orrelated to the clinical relevance of each isolate and its reactivity with several candidate genetic virulence markers. The strongest corre lation with a virulence phenotype was found for a conserved coding seq uence of the macrophage-induced gene mig identified by a specific mig restriction fragment length polymorphism type.