PACLITAXEL (TAXOL)-INDUCED KILLING OF LEISHMANIA-MAJOR IN MURINE MACROPHAGES

Authors
DOHERTY TM SHER A VOGEL SN
Citation
Tm. Doherty et al., PACLITAXEL (TAXOL)-INDUCED KILLING OF LEISHMANIA-MAJOR IN MURINE MACROPHAGES, Infection and immunity, 66(9), 1998, pp. 4553-4556
Citations number
29
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
66
Issue
9
Year of publication
1998
Pages
4553 - 4556
Database
ISI
SICI code
0019-9567(1998)66:9<4553:P(KOLI>2.0.ZU;2-B
Abstract
The antitumor drug paclitaxel (Taxol) has been demonstrated to be a li popolysaccharide mimetic in murine macrophages. In this study, the cap acity of paclitaxel to activate macrophages to become microbicidal for Leishmania major was examined. Paclitaxel and gamma interferon synerg ized to kill intracellular L. major in Lps(n), but not Lps(d), macroph ages by a nitric oxide (NO.)-dependent mechanism.