E-SELECTINS AND P-SELECTINS ARE NOT REQUIRED FOR RESISTANCE TO SEVEREMURINE LYME ARTHRITIS

Borrelia burgdorferi-induced arthritis in mice is characterized by ten donitis, synovitis, and inflammatory-cell infiltrate, predominantly of neutrophils. Because genetic deficiency in E and P selectins results in delayed recruitment of neutrophils to sites of inflammation, mice w ith this deficiency were tested for their response to infection with B . burgdorferi. E and P selectins were not required for the control of B. burgdorferi numbers, nor did deficiency in E and P selectins result in alteration of arthritis severity.