VISCOSITY B-COEFFICIENTS AND PARTIAL MOLAR VOLUMES OF KNOWN DRUGS (ASSALTS)

Viscosity B-coefficients of a number of drugs (viz. hydrochlorides of cyproheptadine, chlorpromazine, ethambutol, amodiaquin and pheniramine maleate) in water have been determined at three different temperature s (293, 298 and 303 k). Thf single loll B+ values have been found to b e high and positive but thedB(+)/dT values have been found to be negat ive. All drug cations can be regarded to be highly structure-making in character and highly solvated. This is due to hydrophobic hydrations of the drug molecules. The activation parameters have been found to be very high and positive. Naturally the drug diffusion through the solu tion is extremely slow. The partial molar volumes of the drug molecule s have been found to be high.