M. Lifshits et al., FATAL PARAPHENYLENEDIAMINE (HAIR DYE) INTOXICATION IN A CHILD RESEMBLING LUDWIGS ANGINA, Journal of toxicology. Clinical toxicology, 31(4), 1993, pp. 653-656
A 6 year-old child with paraphenylenediamine intoxication is presented
. The patient suffered from sore throat, cough, and anorexia, followed
by severe dyspnea caused by edema of the tongue, pharynx, and neck, r
enal failure. and metabolic acidosis. A presumptive diagnosis of Ludwi
g's angina, a severe anaerobic infection of the sublingual neck space,
was entertained. Despite institution of vigorous supportive therapy a
nd administration of antibiotics, the child developed irreversible ven
tricular fibrillation and died eight hours after admission. Two days a
fter the patient's death, his father recalled that the child and his d
og ingested an unidentified substance shortly before the onset of the
child's symptoms. The dog died within a few hours. The substance was i
dentified as the hair dye, paraphenylenediamine.