THE MOUSE GENE ENCODING THE PEROXISOMAL MEMBRANE-PROTEIN 1-LIKE PROTEIN (PXMP1-L) - CDNA CLONING, GENOMIC ORGANIZATION AND COMPARATIVE EXPRESSION STUDIES

PXMP1-L (synonyms: PMP69, P70R) is a peroxisomal protein that belongs to the ABC-transporter superfamily, Its closest homolog is the peroxis omal membrane protein 1 (PMP70), We have cloned the mouse PXMP1-L gene . It encodes a 606 amino acid protein. In contrast to the human and th e rat, mouse PXMP1-L is predominantly expressed in the liver. The mous e PXMP1-L gene consists of 19 exons and spans 21 kb of genomic sequenc e. No obvious peroxisome proliferator response element has been found in 1.1 kb of the putative promoter region. No coordination of constitu tive or fenofibrate-induced expression of PXMP1-L with other peroxisom al ABC transporters was observed so that an obligate exclusive heterod imer formation is not likely to occur. The data presented will be part icularly useful for the generation of a mouse model defective in PXMP1 -L in order to elucidate the yet unknown function of this protein. (C) 1998 Federation of European Biochemical Societies.