Down's syndrome patients are prone to cervical ligamentous laxity, the
vast majority of which is at the C1/2 level. We describe the case of
a 2-year-old girl with Down's syndrome who was found to have cervical
instability at the C2/3 level on screening cervical spine radiographs
with 9 mm of anterolisthesis of C2 on C3. She was without clinically e
vident neurological deficit from this condition; however, T-2-weighted
magnetic resonance imaging of her cervical spine revealed high intens
ity signal changes within the spinal cord at and above that level. She
underwent posterior fusion that was complicated by poor tolerance of
her Minerva-type cervical brace. She eventually developed a stable fus
ion with 5 mm of anterolisthesis at the C2/3 level. This is the only D
own's syndrome patient with instability at the C2/3 level that we have
found reported. Our experience suggests that Down's syndrome patients
can have instability at C2/3 that can be successfully treated with po
sterior fusion.