AN IMPROVED SYNTHESIS OF A MIXTURE OF DIETHYL (Z)- AND (E)-3-METHYLGLUTACONATES FROM ETHYL ACETOACETATE

Authors
KUCHKOVA KI MORARI AB VLAD PF
Citation
Ki. Kuchkova et al., AN IMPROVED SYNTHESIS OF A MIXTURE OF DIETHYL (Z)- AND (E)-3-METHYLGLUTACONATES FROM ETHYL ACETOACETATE, Synthesis, (12), 1993, pp. 1221-1222
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
12
Year of publication
1993
Pages
1221 - 1222
Database
ISI
SICI code
0039-7881(1993):12<1221:AISOAM>2.0.ZU;2-7
Abstract
A simple, efficient two-step synthesis of a mixture of diethyl (Z)- an d (E)-3-methylglutaconates from isodehydroacetic acid in 83% yield is described. On the basis of this synthesis an improved procedure for th e preparation of a mixture of (Z)- and (E)-3-methylglutaconic acids fr om ethyl acetoacetate in 44% overall yield was elaborated.