Fa. Johnson et al., THE USE OF IMAGE-ANALYSIS AS A MEANS OF MONITORING BUBBLE FORMATION IN ALGINATE RAFTS, International journal of pharmaceutics, 170(2), 1998, pp. 179-185
The use of image analysis as a means of measuring the dimensions of bu
bbles produced using a range of alginate raft formulations is describe
d. Raft-forming mixes containing three sodium alginate samples (LFR 5/
60, LF 120M and LF 10/40RB) were prepared, using sodium and potassium
bicarbonate as gas-generating agents, and calcium and zinc carbonates
as sources of divalent cations. The perimeters, areas and mean diamete
rs of the bubbles were ascertained and an index described whereby the
sphericity of the bubbles may be quantified. Systems produced using LF
R 5/60 were found to produce the largest bubbles overall. Comparison w
ith rheological studies indicated that this alginate sample produced t
he lowest viscosity mixes, suggesting a correlation between the viscos
ity of the medium in which the bubbles form and the subsequent bubble
size. (C) 1998 Elsevier Science B.V. All rights reserved.