EFFECTS OF PREPARATION CONDITIONS ON THE MONODISPERSITY OF ALBUMIN MICROSPHERES

Authors
ELMAHDY M IBRAHIM ES SAFWAT S ELSAYED A OHSHIMA H MAKINO K MURAMATSU N KONDO T
Citation
M. Elmahdy et al., EFFECTS OF PREPARATION CONDITIONS ON THE MONODISPERSITY OF ALBUMIN MICROSPHERES, Journal of microencapsulation, 15(5), 1998, pp. 661-673
Citations number
30
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Applied","Engineering, Chemical
Journal title
Journal of microencapsulation → ACNP
ISSN journal
02652048
Volume
15
Issue
5
Year of publication
1998
Pages
661 - 673
Database
ISI
SICI code
0265-2048(1998)15:5<661:EOPCOT>2.0.ZU;2-P
Abstract
Monodisperse albumin microspheres were successfully prepared by both c hemical or thermal hardening methods via membrane emulsification using microporous glass membranes with uniform pore sizes. The monodispersi ty of the microspheres was found to depend strongly on parameters such as albumin concentration, emulsifier concentration, and volume ratio of the internal aqueous phase (albumin solution) to the dispersion med ium (organic solvent). The optimum conditions for obtaining monodisper se albumin microspheres are described.