The authors review the clinical and diagnostic aspects involved in lep
tomeningeal disease due to solid tumours, leukaemias and lymphomas. Th
e importance of the combination of clinical findings with cerebral spi
nal fluid (CSF) examination and imaging studies in making an early dia
gnosis is underlined. The raising prevalence of this complication of s
ystemic cancer deserves specific attention on the part of neurologists
involved in consultation liason with general medicine and oncology.