P. Mayorga et al., RODENT MALARIA PROPHYLAXIS BY TRANSDERMAL DELIVERY OF PRIMAQUINE, International journal for parasitology, 28(8), 1998, pp. 1283-1285
The efficacy of a new transdermal delivery system of primaquine in ord
er to obtain causal prophylaxis against sporozoite-induced Plasmodium
yoelii infection was evaluated. A single administration of a 1.0 cm(2)
transdermal delivery system containing 5.0 mg of primaquine was able
to protect 100% of treated mice. This result suggests that the transde
rmal route may be a Very interesting approach for malaria prophylaxis
and should encourage further studies in order to determine the absolut
e bioavailability of the drug as well as its dose-effect relationship.
(C) 1998 Australian Society for Parasitology. Published by Elsevier S
cience Ltd.