DETECTION OF ANTI-TYPE-VII COLLAGEN ANTIBODY IN SJOGRENS-SYNDROME LUPUS-ERYTHEMATOSUS OVERLAP SYNDROME WITH TRANSIENT BULLOUS SYSTEMIC LUPUS-ERYTHEMATOSUS

Bullous systemic lupus erythematosus (SLE) is a chronic, widespread, n on-scarring, subepidermal blistering eruption associated with autoimmu nity to type VII collagen. Mie describe a patient with Sjogren's syndr ome/lupus erythematosus overlap syndrome who showed transient blisteri ng eruptions over limited skin surface and in oral mucosa, At the time of aggravation, the patient's serum contained IgG autoantibodies that bound to the dermal side of 1 mol/L NaCl-split normal skin, as determ ined by an indirect immunofluorescence test, and that reacted to type VII collagen, as determined by immunoblotting on dermal extract. Our o bservations suggest that a chronic, widespread, blistering eruption is not a prerequisite for the diagnosis of bullous SLE, and a mild, tran sient, blistering eruption could be a manifestation of type I bullous SLE.