DEMETHYL MUTACTIMYCINS, NEW ANTHRACYCLINE ANTIBIOTICS FROM NOCARDIA AND STREPTOMYCES STRAINS

Authors
SPEITLING M NATTEWAN P YAZAWA K MIKAMI Y GRUNWOLLNY I RITZAU M LAATSCH H GRAFE U
Citation
M. Speitling et al., DEMETHYL MUTACTIMYCINS, NEW ANTHRACYCLINE ANTIBIOTICS FROM NOCARDIA AND STREPTOMYCES STRAINS, Journal of antibiotics, 51(8), 1998, pp. 693-698
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology,"Biothechnology & Applied Migrobiology",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
51
Issue
8
Year of publication
1998
Pages
693 - 698
Database
ISI
SICI code
0021-8820(1998)51:8<693:DMNAAF>2.0.ZU;2-A
Abstract
New anthracycline antibiotics 3'-O-demethyl mutactimycin (3) and 4-O,3 '-O-didemethyl mutactimycin (4) were isolated from two actinomycetes s trains, Nocardia transvalensis and Streptomyces sp. GW 60/1571. The ch emical structures were elucidated by mass spectrometry and NMR spectro scopy. Antibiotic 3 displayed moderate antimicrobial activity against Gram-positive bacteria and cytotoxicity against P388, L1210 and HeLa t umor cells (IC50; 9.6, > 25 and 20 mu g/ml, respectively).