FINE LOCALIZATION OF THE GENE FOR CENTRAL AREOLAR CHOROIDAL DYSTROPHYON CHROMOSOME 17P

Central areolar choroidal dystrophy (CACD) is a retinal disease which causes progressive profound loss of vision in patients during middle a ge. The disease is inherited as an autosomal dominant trait and shows genetic heterogeneity. Mutations in the peripherin-RDS gene on chromos ome 6 have been reported in affected members of families transmitting the disease. A new locus at chromosome 17p13 was identified recently b y a genome wide Linkage search in members of a large Northern Irish fa mily. We now report the refinement of the critical region for this gen e to an interval of approximately 5 cM flanked by polymorphic markers D17S1810 and CHLC GATA7B03.