Perfusion and ventilation abnormalities created by pleural effusions c
an interfere with the interpretation of the lung scan. This retrospect
ive study identified and evaluated the specificity of scintigraphic pa
tterns for pleural effusion. Ninety-two ventilation-perfusion lung sca
ns were analyzed for the following signs of pleural effusion: presence
of fissures, straightened or concave lung borders, costophrenic angle
blunting, and attenuation of lung activity by interposed fluid. The f
indings later were correlated with chest radiographs. Of 25 pleural ef
fusions detected by chest radiography, scintigraphy predicted 14 (spec
ificity, 86%). In all of these cases, there was agreement with the che
st radiograph (specificity, 100%). The fissure sign and the straight-
concave border sign were equally reliable for the prediction of pleura
l fluid. Costophrenic angle blunting was never seen as the sole indica
tor of pleural fluid, and attenuation was seen alone in only one case.
Another finding observed during this evaluation was absent ventilatio
n at the lung base with preserved perfusion. Scintigraphic patterns ma
y not be reliable in obstructive lung disorders and diseases with alte
red lung compliance. The recognition of scintigraphic patterns of pleu
ral effusions on ventilation-perfusion scans can improve the clinical
value of lung scintigraphy by reducing the number of indeterminate rea
dings.