V. Kuberkar et al., FLUX ENHANCEMENT FOR MEMBRANE FILTRATION OF BACTERIAL SUSPENSIONS USING HIGH-FREQUENCY BACKPULSING, Biotechnology and bioengineering, 60(1), 1998, pp. 77-87
A promising method for reducing membrane fouling during crossflow micr
ofiltration of biological suspensions is backpulsing. Very short backp
ulses (0.1-1.0 s) have been used to increase the net flux for washed b
acterial suspensions and whole bacterial fermentation broths. The net
fluxes under optimum backpulsing conditions for the washed bacteria ar
e approximately 10-fold higher than those obtained during normal cross
flow microfiltration operation, whereas only a 2-fold improvement in t
he net flux is achieved for the fermentation broths. A theory is prese
nted that is based on external fouling during forward filtration and n
onuniform cleaning of the membrane during reverse filtration. The mode
l contains an adjustable parameter which is a measure of the cleaning
efficiency during backpulsing; the cleaning efficiency found by fittin
g the model to the experiments increases with increasing frequency and
duration of the backpulses. The theory predicts an optimum backpulsin
g frequency, as was observed experimentally. An economic analysis show
s that crossflow microfiltration with backpulsing has lower costs than
centrifugation, rotary vacuum filtration, and crossflow microfiltrati
on without backpulsing. (C) 1998 John Wiley & Sons, Inc.