SPRING TIME AND AUTUMN TIME TOXIC EFFECTS OF COPPER(II), 3-(2-FURYL)PROP-2-ENAL SEMICARBAZONE AND [CUCL2(FASC)(2)] COMPLEX IN MICE

In vitro, 3-(2-furyl) prop-2-enal semicarbazone-copper (II) complex [C uCl2(FASC)(2)] presents antimitotic effects. In this work we studied t he in vivo seasonal toxic effects in male Swiss mice of CuCl2, and FAS C and the [CuCl2(FASC)(2)] complex. In spring, one injection of CuCl2 8.10(-2) mmol killed 16% of animals after 24 h. Cupric chloride lethal dose was up to 64.10(-2) mmol with 100% mice dead after 24 h. FASC wa s well tolerated from 0.65 to 1.3 mmol. The complex was 100% lethal wi th 48.10(-2) mmol. In autumn, mice were more sensitive to CuCl2 and to the complex with lethal doses up to 32.10(-2) mmol and 8.10(-2) mmol, respectively. On the other hand, FASC was well tolerated. It is concl uded that the in vivo toxic effects of CuCl2 and [CuCl2(FASC)(2)] comp lex are quite different in spring and autumn.