CORRELATIONAL RELATIONSHIP BETWEEN SHOCK-INTENSITY AND CORTICOSTERONESECRETION ON THE ESTABLISHMENT AND SUBSEQUENT EXPRESSION OF CONTEXTUAL FEAR CONDITIONING
Mi. Cordero et al., CORRELATIONAL RELATIONSHIP BETWEEN SHOCK-INTENSITY AND CORTICOSTERONESECRETION ON THE ESTABLISHMENT AND SUBSEQUENT EXPRESSION OF CONTEXTUAL FEAR CONDITIONING, Behavioral neuroscience, 112(4), 1998, pp. 885-891
A role for corticosterone in the consolidation of contextual fear cond
itioning has previously been proposed. In this study, physiological ev
idence was found to support this view. The extent of conditioned fear
and the levels of plasma corticosterone in rats, after context exposur
e at training and at different posttraining times (24 hr and 7 days),
depended on the intensity of the unconditional stimulus (footshock). I
n each experimental session, a positive correlation was found between
the magnitude of corticosterone levels and the fear-related behavioral
inhibition exhibited in the context. Results support the involvement
of corticosterone on the processes that occur during consolidation in
determining the strength at which the contextual fear conditioning is
stored as a long-term memory.