PTERIN 1H-3H TAUTOMERISM AND ITS POSSIBLE RELEVANCE TO THE BINDING OFFOLATE TO DIHYDROFOLATE-REDUCTASE

Authors
SCHWALBE CH LOWIS DR RICHARDS WG
Citation
Ch. Schwalbe et al., PTERIN 1H-3H TAUTOMERISM AND ITS POSSIBLE RELEVANCE TO THE BINDING OFFOLATE TO DIHYDROFOLATE-REDUCTASE, Journal of the Chemical Society, Chemical Communications, (15), 1993, pp. 1199-1200
Citations number
13
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
15
Year of publication
1993
Pages
1199 - 1200
Database
ISI
SICI code
0022-4936(1993):15<1199:P1TAIP>2.0.ZU;2-X
Abstract
Ab initio and free energy perturbation calculations slow that the 1H:3 H tautomer ratio is 1:6 for pterin in aqueous solution, implying that the 1H tautomer of folate may be responsible for non-productive bindin g to dihydrofolate reductase.