EVIDENCE THAT ARGININE IS A LATER METABOLIC INTERMEDIATE THAN ORNITHINE IN THE BIOSYNTHESIS OF CLAVULANIC ACID BY STREPTOMYCES-CLAVULIGERUS

Authors
VALENTINE BP BAILEY CR DOHERTY A MORRIS J ELSON SW BAGGALEY KH NICHOLSON NH
Citation
Bp. Valentine et al., EVIDENCE THAT ARGININE IS A LATER METABOLIC INTERMEDIATE THAN ORNITHINE IN THE BIOSYNTHESIS OF CLAVULANIC ACID BY STREPTOMYCES-CLAVULIGERUS, Journal of the Chemical Society, Chemical Communications, (15), 1993, pp. 1210-1211
Citations number
11
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
15
Year of publication
1993
Pages
1210 - 1211
Database
ISI
SICI code
0022-4936(1993):15<1210:ETAIAL>2.0.ZU;2-7
Abstract
The feeding of radiolabelled ornithine and arginine to mutants of Stre ptomyces clavuliyerus auxotrophic for arginine has shown that ornithin e has to be converted to arginine prior to incorporation into clavulan ic acid.