THE IDENTIFICATION OF 3 NEW BIOSYNTHETIC INTERMEDIATES AND ONE FURTHER BIOSYNTHETIC ENZYME IN THE CLAVULANIC ACID PATHWAY

Authors
ELSON SW BAGGALEY KH DAVISON M FULSTON M NICHOLSON NH RISBRIDGER GD TYLER JW
Citation
Sw. Elson et al., THE IDENTIFICATION OF 3 NEW BIOSYNTHETIC INTERMEDIATES AND ONE FURTHER BIOSYNTHETIC ENZYME IN THE CLAVULANIC ACID PATHWAY, Journal of the Chemical Society, Chemical Communications, (15), 1993, pp. 1212-1214
Citations number
20
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
15
Year of publication
1993
Pages
1212 - 1214
Database
ISI
SICI code
0022-4936(1993):15<1212:TIO3NB>2.0.ZU;2-Y
Abstract
Labelling experiments are described that identify three new compounds, N2-(2-carboxyethyl)arginine, 5-guanidino-(2-oxoazetidin-1-yl)pentanoi c acid, and ydroxy-5-guanidino-2-(2-oxoazetidin-1-yl)pentanoic acid as biosynthetic precursors of proclavaminic acid and hence clavulanic ac id in Streptomyces clavuligerus ATCC 27064 and a new amidino hydrolase , which hydrolyses ydroxy-5-guanidino-2-(2-oxoazetidin-1-yl)pentanoic acid to proclavaminic acid has been characterised.