FUNCTIONAL-ORGANIZATION OF SACCADES AND ANTISACCADES IN THE FRONTAL-LOBE IN HUMANS - A STUDY WITH ECHO-PLANAR FUNCTIONAL MAGNETIC-RESONANCE-IMAGING

Authors
MURI RM HEID O NIRKKO AC OZDOBA C FELBLINGER J SCHROTH G HESS CW
Citation
Rm. Muri et al., FUNCTIONAL-ORGANIZATION OF SACCADES AND ANTISACCADES IN THE FRONTAL-LOBE IN HUMANS - A STUDY WITH ECHO-PLANAR FUNCTIONAL MAGNETIC-RESONANCE-IMAGING, Journal of Neurology, Neurosurgery and Psychiatry, 65(3), 1998, pp. 374-377
Citations number
23
Categorie Soggetti
Psychiatry,"Clinical Neurology",Surgery
Journal title
Journal of Neurology, Neurosurgery and Psychiatry → ACNP
ISSN journal
00223050
Volume
65
Issue
3
Year of publication
1998
Pages
374 - 377
Database
ISI
SICI code
0022-3050(1998)65:3<374:FOSAAI>2.0.ZU;2-5
Abstract
The cortical activation pattern of saccades and antisaccades (versus r est) in the frontal lobe was analysed using an echo planar imaging (EP I) technique in 10 healthy subjects. Statistical analysis of activity in the dorsolateral prefrontal cortex disclosed a significantly greate r activation during antisaccades in this region than during saccades. On the other hand, activity in the frontal eye fields was not statisti cally different in both tasks. These results confirm the important rol e of the dorsolateral prefrontal cortex for the correct performance of antisaccades obtained by studies in humans with isolated lesions of t he dorsolateral prefrontal cortex.