The usefulness of cognitive rehabilitative treatment in the acute stag
es after brain injury seems questionable because patients in severe ac
ute confusional state early after coma clinically seem unable to learn
and store new information. Therefore, the capability of patients in a
cute confusional state to learn and retain associative information was
assessed. On two occasions pairs of simple nouns were presented to si
x patients in severe acute confusional state. Stimuli were presented r
epeatedly either in written form only or with additional pictorial rep
resentations. Immediate and 20 minutes delayed recall was measured. Pa
tients in acute confusional state were able to learn progressively mor
e word pairs across several presentations. They retained some informat
ion over an interval of 20 minutes. In addition, they learned and reme
mbered pictorially supported associations better than pure verbal asso
ciations. Patients in severe acute confusional state may retain some e
xplicit information and may profit from an imagery mnemonic aid. These
results were not expected on the basis of clinical findings alone and
they have potential implications for the care of patients in acute co
nfusional state.