Es. Andersen et al., COMBINATION LASER CONIZATION AS TREATMENT OF MICROINVASIVE CARCINOMA OF THE UTERINE CERVIX, European journal of gynaecological oncology, 19(4), 1998, pp. 352-355
During the period June 1985 to August 1992 combination laser conizatio
n was considered definite therapy in 41 patients with microinvasive ca
rcinoma of the cervix. Selection criteria for conservative, fertility-
saving therapy were: invasion 3 mm or less, no lymphovascular involvem
ent and horizontal spread of 7 mm or less. After treatment patients we
re followed for 5 to 12 years, mean follow-up 81 months, and mean numb
er of examination was 10. In one cases, adenocarcinoma in situ was dia
gnosed during follow-up. In all other cases persistent or recurrent di
sease was not diagnosed during follow-up. By thorough histopathologic
evaluation and strict criteria for selection of patients, it was possi
ble to perform conservative treatment with no observed risk of undertr
eatment. Combination laser conization was a useful treatment modality.
A follow-up regimen based on colposcopy and cytology proved sufficien
t.