A NOVEL PHOSPHORYLATED LIPID COUNTERACTS ACTIVATION OF THE RENAL PLASMA-MEMBRANE (CA2-4-PHOSPHATE(+MG2+)ATPASE BY ENDOGENOUS PHOSPHATIDYLINOSITOL)

Authors
GUILHERME A REISSILVA C MORAESALBUQUERQUE JH OLIVEIRA MM VIEYRA A
Citation
A. Guilherme et al., A NOVEL PHOSPHORYLATED LIPID COUNTERACTS ACTIVATION OF THE RENAL PLASMA-MEMBRANE (CA2-4-PHOSPHATE(+MG2+)ATPASE BY ENDOGENOUS PHOSPHATIDYLINOSITOL), Bioscience reports, 18(2), 1998, pp. 79-89
Citations number
27
Categorie Soggetti
Cell Biology",Biology
Journal title
Bioscience reports → ACNP
ISSN journal
01448463
Volume
18
Issue
2
Year of publication
1998
Pages
79 - 89
Database
ISI
SICI code
0144-8463(1998)18:2<79:ANPLCA>2.0.ZU;2-R
Abstract
The plasma membrane (Ca2+ + Mg2+)ATPase is activated by acidic phospho lipids in reconstituted systems. In this report it is shown that rever sible phosphorylation of endogenous phosphatidylinositol regulates the renal plasma membrane (Ca2+ + Mg2+)ATPase, and that a novel phosphory lated lipid that can be isolated from the same membrane strongly count eracts the stimulatory effect of phosphatidylinositol-4-phosphate.