LEIOMYOSARCOMA ASSOCIATED WITH EPSTEIN-BARR-VIRUS IN AN ADULT WITH RENAL-TRANSPLANT

Recently the association between the Epstein-Barr virus (EBV) and smoo th muscle lesions has been described in immunosuppressed children but it is infrequent in adults. The role of EBV in the pathogenesis of the se lesions is obscure. We presents a 28 year old man with end stage re nal disease transplanted in 1994. Two years later he developed several nodular lesions that affected both lungs, liver, spleen, retroperiton eal ganglia and the left thigh; one year later he died. The surgical s pecimen from the thigh and a liver biopsy were diagnosed as leiomyosar coma. Immunohistochemical reactions against vimentin and smooth muscle actin were positive. In situ hybridization disclosed positivity again st EBV nuclear antigens (EBNA-2) in neoplasic cells. This is the first case of sarcoma in transplanted patients of our institution and repre sents a rare case of leiomyosarcoma associated with EBV in adults.