BRIEF CLINICAL REPORT - CRANIOFACIAL DYSSYNOSTOSIS - A FURTHER CASE-REPORT

I describe a boy with lambdoid craniosynostosis, severe global develop mental delay, epilepsy, oculomotor dyspraxia, very thin corpus callosu m, and minor anomalies, The phenotype is in keeping with a diagnosis o f craniofacial dyssynostosis. This autosomal recessive condition was f irst described in 1976 and was originally predicted to be relatively c ommon in those of Spanish descent. However, there have been no further reports of the condition, This case is remarkably similar to those pr eviously described, but has the additional finding of a neuronal migra tion defect, (C) 1998 Wiley-Liss, Inc.