THE PCD GENE ENCODING PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE INVOLVED IN BIOSYNTHESIS OF ALPHA-AMINOADIPIC ACID IS LOCATED IN THE CEPHAMYCIN CLUSTER OF STREPTOMYCES-CLAVULIGERUS

Authors
PEREZLLARENA FJ RODRIGUEZGARCIA A ENGUITA FJ MARTIN JF LIRAS P
Citation
Fj. Perezllarena et al., THE PCD GENE ENCODING PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE INVOLVED IN BIOSYNTHESIS OF ALPHA-AMINOADIPIC ACID IS LOCATED IN THE CEPHAMYCIN CLUSTER OF STREPTOMYCES-CLAVULIGERUS, Journal of bacteriology, 180(17), 1998, pp. 4753-4756
Citations number
16
Categorie Soggetti
Microbiology
Journal title
Journal of bacteriology → ACNP
ISSN journal
00219193
Volume
180
Issue
17
Year of publication
1998
Pages
4753 - 4756
Database
ISI
SICI code
0021-9193(1998)180:17<4753:TPGEPD>2.0.ZU;2-4
Abstract
Three open reading frames (ORFs) have been located downstream of cefE in the cephamycin C gene cluster of Streptomyces clavuligerus. ORF13 ( pcd) encodes a 496-amino-acid protein (molecular weight [MW], 52,488) with an N-terminal amino acid sequence identical to that of pure piper ideine-6-carboxylate dehydrogenase, ORF14 (cmcT) encodes a 523-amino-a cid protein (MW, 54,232) analogous to Streptomyces proteins for efflux and resistance to antibiotics. ORF15 (pbp74) encodes a high molecular weight penicillin-binding protein (MW, 74,094).