THE PCD GENE ENCODING PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE INVOLVED IN BIOSYNTHESIS OF ALPHA-AMINOADIPIC ACID IS LOCATED IN THE CEPHAMYCIN CLUSTER OF STREPTOMYCES-CLAVULIGERUS
Fj. Perezllarena et al., THE PCD GENE ENCODING PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE INVOLVED IN BIOSYNTHESIS OF ALPHA-AMINOADIPIC ACID IS LOCATED IN THE CEPHAMYCIN CLUSTER OF STREPTOMYCES-CLAVULIGERUS, Journal of bacteriology, 180(17), 1998, pp. 4753-4756
Three open reading frames (ORFs) have been located downstream of cefE
in the cephamycin C gene cluster of Streptomyces clavuligerus. ORF13 (
pcd) encodes a 496-amino-acid protein (molecular weight [MW], 52,488)
with an N-terminal amino acid sequence identical to that of pure piper
ideine-6-carboxylate dehydrogenase, ORF14 (cmcT) encodes a 523-amino-a
cid protein (MW, 54,232) analogous to Streptomyces proteins for efflux
and resistance to antibiotics. ORF15 (pbp74) encodes a high molecular
weight penicillin-binding protein (MW, 74,094).