NOVEL APPROACHES TO THE DISCOVERY OF ANTIMICROBIAL AGENTS

With the completion of numerous bacterial genome sequences, the discov ery of antibacterial drugs has fully entered the genomic era. The stra tegies for effectively using genomic information for target identifica tion, target characterization, screen development and compound evaluat ion are emerging, and have greatly increased the number of antibacteri al targets available for screening. Fortunately, simultaneous efforts in improving miniaturization, robotics and database tools are underway so that the potential of genomics can be realized.