CHEMICAL CHARACTERISTICS OF TC-99M-LABELED AMINE OXIMES

A series of alkylene amine oximes including En(AO)2, Pn(AO)2, DmPn(AO) 2, HMPAO, Bn(AO)2 and Pent(AO)2 were synthesized and complexations of the amine oximes with a trace-level of (TcO4-)-Tc-99m were undertaken in the presence of Sn2+ . The Tc-99m-amine oxime complexes obtained we re characterized simultaneously by solvent extraction, TLC, electropho resis and HPLC. The labeling yield, neutrality, lipophilicity and stab ility of the Tc-99m-amine oxime complexes were sufficiently investigat ed. According to the structures found by x-my diffraction in previous literature, the complexes of Tc-99m with the ligands with 2-C and 3-C backbones including En(AO)2, Pn(AO)2, DmPn(AO)2 and HMPAO in the pres ent work! are in the form of TcOL, where L is the ligand involved, whe reas those with 4-C and 5-C backbones including Bn(AO)2 and Pent(AO)2 ! are in the form of TcO2L. The chemical behaviors of the complex of n o-carrier-added Tc-99m with the ligands found in observed study correl ate with the TcOL-type and the TcO2L-type structures aforementioned.