The existence of a local renin/angiotensin system in the intestine of
mammals is speculative despite the known importance of angiotensin II
for water and electrolyte homeostasis. We demonstrate the presence of
ren-2 transcripts in the small intestine of DBA/2 mice. The marked exp
ression of the ren-2 gene is blunted tissue-specifically by starvation
, corroborating a local renin/angiotensin system in this organ.