THE RISK FOR OUTPATIENT ANTIBIOTIC-TREATED INFECTIONS FOLLOWING A COURSE OF ORAL CORTICOSTEROIDS AMONG CHILDREN WITH ASTHMA

Short courses of oral corticosteroids are widely used to treat asthma. The objective of this study was to assess ii one course of oral corti costeroids increases asthmatic children's risk for infections treated with outpatient antibiotics. Using New York State Medicaid claims data on asthmatic children 2-15 years old, we made cohorts of oral cortico steroid users and nonusers. We determined the percentage of children w ho filled antibiotic prescriptions in the 30 days after index dates. I ndex dates were dates oral steroids were started (for steroid users) o r matched dates (for nonusers). Odds ratios were adjusted for age, mon th of index date, and prior antibiotic use. Among children not receivi ng antibiotics on index dates, antibiotic prescriptions were filled in the next 30 days for 438 (20%) of 2145 steroid nonusers and 130 (19%) of 698 steroid users (p = 0.30); compared to nonusers, steroid users had an adjusted odds ratio of subsequent antibiotic use of 0.92 (95% c onfidence interval [Cl] 0.73-1.15). Among children receiving antibioti cs on index dates, antibiotic prescriptions were filled in the next 30 days for 116 (26%) of 451 steroid nonusers and 50 (19%) of 260 steroi d users (p = 0.05); compared to nonusers, steroid users had an adjuste d odds ratio of subsequent antibiotic use of 0.65 (95% CI 0.53-0.97), We conclude that one course of oral corticosteroids does not increase asthmatic children's risk for infections treated with outpatient antib iotics.