TETRAFIBRICIN, A NOVEL FIBRINOGEN RECEPTOR ANTAGONIST .2. STRUCTURAL ELUCIDATION

Authors
KAMIYAMA T ITEZONO Y UMINO T SATOH T NAKAYAMA N YOKOSE K
Citation
T. Kamiyama et al., TETRAFIBRICIN, A NOVEL FIBRINOGEN RECEPTOR ANTAGONIST .2. STRUCTURAL ELUCIDATION, Journal of antibiotics, 46(7), 1993, pp. 1047-1054
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
7
Year of publication
1993
Pages
1047 - 1054
Database
ISI
SICI code
0021-8820(1993)46:7<1047:TANFRA>2.0.ZU;2-R
Abstract
The structure of tetrafibricin, a novel and potent fibrinogen receptor antagonist isolated from the culture broth of Streptomyces neyagawaen sis NR0577, was determined. Tetrafibricin has a unique structure conta ining primary amine, conjugated tetraenoic acid, and polyhydroxy funct ionalities that is biosynthetically related to the polyene macrolide a ntibiotics.