THE SYNTHESIS AND BIOLOGICAL PROPERTIES OF ARTIFICIAL ANTIGENS ON THEBASIS OF THE 280-289 FRAGMENT OF BETA(2)-GLYCOPROTEIN-I

Authors
PALKEEVA ME SIDOROVA MV MOLOKOEDOV AS KUZNETSOVA TV TISHCHENKO VA KOBYLYANSKII AG BESPALOVA ZD NASONOV EL EVSTIGNEEVA RP
Citation
Me. Palkeeva et al., THE SYNTHESIS AND BIOLOGICAL PROPERTIES OF ARTIFICIAL ANTIGENS ON THEBASIS OF THE 280-289 FRAGMENT OF BETA(2)-GLYCOPROTEIN-I, Bioorganiceskaa himia, 24(7), 1998, pp. 502-508
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear",Biology
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
24
Issue
7
Year of publication
1998
Pages
502 - 508
Database
ISI
SICI code
0132-3423(1998)24:7<502:TSABPO>2.0.ZU;2-Q
Abstract
A series of artificial antigens were synthesized on the basis of the F C(Acm)KNKEKKC(Acm)S peptide from the beta(2)-glycoprotein I sequence: lipophilic analogues, the peptide-BSA conjugate, and multiple antigen peptide (MAP) containing eight copies of the peptide on an oligolysyl core. The solid phase method for acylation of the peptide with fatty a cids and the HPLC analysis of the acylpeptides were described. antigen ic properties of the resulting compounds were evaluated by CL-ELISA.