A NOVEL MACROLACTAM-DISACCHARIDE ANTIFUNGAL ANTIBIOTIC - TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL PROPERTIES, STRUCTURE ELUCIDATION AND BIOLOGICAL-ACTIVITY

A novel natural product (1), with antifungal activity was isolated fro m the culture broth of an actinomadurae. The active compound was separ ated from broth by n-butanol extraction and purified by silica gel and multicoil counter current chromatography. Physico-chemical data sugge sted the structure of this compound to be a novel macrolactam disaccha ride related to Sch 38518 (3). The structure was determined by spectro scopic studies on the acetate derivative. It was active against Candid a spp. (MIC's, 4 approximately 64 mug/ml) but less active than the mon osaccharide, Sch 38518 (MIC's, 1 approximately 16 mug/ml).