PC-766B, A NEW MACROLIDE ANTIBIOTIC PRODUCED BY NOCARDIA-BRASILIENSIS.2. ISOLATION, PHYSICOCHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION

Authors
KUMAGAI K FUKUI A TANAKA S IKEMOTO M MORIGUCHI K NABESHIMA S
Citation
K. Kumagai et al., PC-766B, A NEW MACROLIDE ANTIBIOTIC PRODUCED BY NOCARDIA-BRASILIENSIS.2. ISOLATION, PHYSICOCHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION, Journal of antibiotics, 46(7), 1993, pp. 1139-1144
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
7
Year of publication
1993
Pages
1139 - 1144
Database
ISI
SICI code
0021-8820(1993)46:7<1139:PANMAP>2.0.ZU;2-J
Abstract
A new macrolide antibiotic, PC-766B, was isolated from the cells of No cardia brasiliensis SC-4710 by acetone extraction, and purified by gel filtration, silica gel chromatography, HPLC and TLC. The structure of PC-766B was determined by NMR spectral analysis to be a new class of the hygrolidin family antibiotics. PC-766B had a 16-membered macrocycl ic lactone ring, a 6-membered hemiketal ring and a 2-deoXy-D-rhamnose moiety. DL-alpha-Tocopherol, known as an antioxidant agent, significan tly improved the stability of PC-766B and prevented the decomposition of PC-766B during the storage of the antibiotic.