TAUTOMERIC PHENOMENON OF A NOVEL POTENT IMMUNOSUPPRESSANT (FK506) IN SOLUTION .1. ISOLATION AND STRUCTURE DETERMINATION OF TAUTOMERIC COMPOUNDS

Authors
NAMIKI Y KIHARA N KODA S HANE K YASUDA T
Citation
Y. Namiki et al., TAUTOMERIC PHENOMENON OF A NOVEL POTENT IMMUNOSUPPRESSANT (FK506) IN SOLUTION .1. ISOLATION AND STRUCTURE DETERMINATION OF TAUTOMERIC COMPOUNDS, Journal of antibiotics, 46(7), 1993, pp. 1149-1155
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
7
Year of publication
1993
Pages
1149 - 1155
Database
ISI
SICI code
0021-8820(1993)46:7<1149:TPOANP>2.0.ZU;2-Q
Abstract
Tautomeric phenomenon was observed in the HPLC chromatogram obtained f rom a novel potent immunosuppressant, FK506, in ethanol solution. Two tautomeric compounds derived from FK506 were isolated and purified by HPLC. Their structures were elucidated by spectral analyses. The mecha nisms for this tautomerization were also established based on the resu lts of structure analysis.