OPTIMIZED ACQUISITION TIME AND IMAGE SAMPLING FOR DYNAMIC SPECT OF TL-201

With the recent development in scatter and attenuation correction algo rithms, dynamic single photon emission computerized tomography (SPECT) cain potentially yield physiological parameters, with tracers exhibit ing suitable kinetics such as thallium-201 (T1-201). a systematic way is proposed to investigate the minimum data acquisition times and sam; ling requirements for estimating physiological parameters with quantit ative dynamic SPECT. Two different sampling schemes were investigated with Monte Carlo simulations: 1) continuous data collection for total study duration ranging from 30-240 min, 2) Continuous data collection for first 10-45 min followed by a delayed study at approximately 3 h, Tissue time activity curves with realistic noise were generated from a mean plasma time activity curve and rate constants (K-1 - k(4)) deriv ed from T1-201 kinetic studies ire 16 dogs, Full dynamic sampling sche dules DynSS) were compared to optimum sampling schedules (OSS). We fou nd that OSS can reliably estimate the blood Wow related K-1 and V-d co mparable to DynSS. A 30-min continuous collection was sufficient if on ly K-1 was of interest, A split session schedule of a 30-min dynamic f ollowed by a static study at 3 h allowed reliable estimation of both K -1 and V-d avoiding the need for a prolonged (>60-min) continuous dyna mic acquisition, The methodology developed should also be applicable t o optimizing sampling schedules for ether SPECT tracers,