OPPOSING TIME TRENDS OF PEPTIC-ULCER AND REFLUX DISEASE

Background - Gastritis associated hypochlorhydria may be protective ag ainst gastro-oesophageal reflux disease. It was hypothesised that the historic decline in Helicobacter pylori infection resulted in a declin e in peptic ulcer and a concomitant rise in reflux disease. Aims - To study the time trends of peptic ulcer and reflux disease. Methods-Hosp italisation rates were analysed using the computerised database of the US Department of Veterans Affairs from 1970 until 1995. Death rates w ere calculated from the Vital Statistics of the United States. Results - From 1970 to 1995, hospitalisation rates for gastric and duodenal u lcer, as well as gastric cancer fell, while the hospitalisation rates for gastro-oesophageal reflux disease and those for oesophageal adenoc arcinoma rose significantly. Similar time trends were observed with re spect to the death rates. There were notable ethnic differences. White subjects incurred higher rates of reflux disease and oesophageal aden ocarcinoma and lower rates of gastric ulcer or cancer compared with no n-whites. Conclusions - The ethnic variations and the opposing time tr ends of gastroduodenal versus oesophageal disease are consistent with the hypothesis that the declining infection rates of H pylori in the g eneral population have led to a rise in the occurrence of gastro-oesop hageal reflux disease and associated oesophageal adenocarcinoma.