Cm. Bladon et al., DELTA-TOXIN AND ANALOGS AS PEPTIDE MODELS FOR PROTEIN ION CHANNELS, Journal of the Chemical Society. Perkin transactions. I, (14), 1993, pp. 1687-1697
Delta-Toxin, six analogues and their acetylated derivatives, have been
synthesised. The model peptides, based on the parent compound 8-toxin
, incorporate components of the proposed pore-forming segments of the
protein ion channels. The backbone conformations of the peptides have
been elucidated by a combination of two-dimensional NMR experiments an
d distance geometry and molecular mechanics calculations. In several o
f the compounds a relatively stable helix is formed but in peptides in
corporating a proline in the centre of the molecule a bend-helix motif
is present.