H. Schneider et al., CLONING AND FUNCTIONAL EXPRESSION OF A HUMAN PARATHYROID-HORMONE RECEPTOR, European journal of pharmacology. Molecular pharmacology section, 246(2), 1993, pp. 149-155
We have cloned a human receptor for parathyroid hormone from a kidney
complementary DNA library. The deduced sequence of 593 amino acids sho
ws high homology to the previously cloned receptors from opossum and r
at. Expressed in COS-1 cells, the human receptor binds to parathyroid
hormone-(1-38) with high affinity (pK(D) = 8.5) and is functionally co
upled to adenylate cyclase (pEC50 = 9.4). At high concentrations of ag
onist, the receptor also activates phosphoinositide turnover.