CLONING AND FUNCTIONAL EXPRESSION OF A HUMAN PARATHYROID-HORMONE RECEPTOR

Authors
SCHNEIDER H FEYEN JHM SEUWEN K MOVVA NR
Citation
H. Schneider et al., CLONING AND FUNCTIONAL EXPRESSION OF A HUMAN PARATHYROID-HORMONE RECEPTOR, European journal of pharmacology. Molecular pharmacology section, 246(2), 1993, pp. 149-155
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology. Molecular pharmacology section → ACNP
ISSN journal
09224106
Volume
246
Issue
2
Year of publication
1993
Pages
149 - 155
Database
ISI
SICI code
0922-4106(1993)246:2<149:CAFEOA>2.0.ZU;2-8
Abstract
We have cloned a human receptor for parathyroid hormone from a kidney complementary DNA library. The deduced sequence of 593 amino acids sho ws high homology to the previously cloned receptors from opossum and r at. Expressed in COS-1 cells, the human receptor binds to parathyroid hormone-(1-38) with high affinity (pK(D) = 8.5) and is functionally co upled to adenylate cyclase (pEC50 = 9.4). At high concentrations of ag onist, the receptor also activates phosphoinositide turnover.