SIMULTANEOUS DETERMINATION OF 6-MONOACETYLMORPHINE, MORPHINE AND CODEINE IN URINE USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH COMBINED ULTRAVIOLET AND ELECTROCHEMICAL DETECTION

Authors
GEROSTAMOULOS J CRUMP K MCINTYRE IM DRUMMER OH
Citation
J. Gerostamoulos et al., SIMULTANEOUS DETERMINATION OF 6-MONOACETYLMORPHINE, MORPHINE AND CODEINE IN URINE USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH COMBINED ULTRAVIOLET AND ELECTROCHEMICAL DETECTION, Journal of chromatography. Biomedical applications, 617(1), 1993, pp. 152-156
Citations number
9
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of chromatography. Biomedical applications → ACNP
ISSN journal
03784347
Volume
617
Issue
1
Year of publication
1993
Pages
152 - 156
Database
ISI
SICI code
0378-4347(1993)617:1<152:SDO6MA>2.0.ZU;2-I
Abstract
A method is described for the simultaneous determination of 6-monoacet ylmorphine (6-MAM), morphine and codeine in postmortem urine specimens using reversed-phase high-performance liquid chromatography with dual ultraviolet spectrophotometric and electrochemical detection. The lim its of detection for a 1-ml urine sample were 0.04 mg/l for 6-MAM and 0.05 mg/l for both morphine and codeine. The presence of 6-MAM in urin e indicates prior use of heroin and enables differentiation between mo rphine- and heroin-related deaths.