EFFICIENT CONSTRUCTION OF NOVEL QUATERNARY LACTAM DIPEPTIDE SURROGATES

Authors
SEMPLE JE
Citation
Je. Semple, EFFICIENT CONSTRUCTION OF NOVEL QUATERNARY LACTAM DIPEPTIDE SURROGATES, Tetrahedron letters, 39(37), 1998, pp. 6645-6648
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
37
Year of publication
1998
Pages
6645 - 6648
Database
ISI
SICI code
0040-4039(1998)39:37<6645:ECONQL>2.0.ZU;2-N
Abstract
Concise, facile synthetic routes to the hindered quaternary alpha-amin olactam intermediates 2, 10 and 12 were developed. These functionalize d intermediates ultimately serve as novel types of Phe/nor-Asp-Pro dip eptide surrogates which in turn are useful as enzyme active site probe s. (C) 1998 Elsevier Science Ltd. All rights reserved.