SOLID-PHASE SYNTHESIS OF BENZIMIDAZOLES

Authors
MAYER JP LEWIS GS MCGEE C BANKAITISDAVIS D
Citation
Jp. Mayer et al., SOLID-PHASE SYNTHESIS OF BENZIMIDAZOLES, Tetrahedron letters, 39(37), 1998, pp. 6655-6658
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
37
Year of publication
1998
Pages
6655 - 6658
Database
ISI
SICI code
0040-4039(1998)39:37<6655:SSOB>2.0.ZU;2-9
Abstract
A readily automated solid-phase approach to the synthesis of diverse b enzimidazoles is described. The procedure utilizes polymer supported 4 -fluoro-3-nitrobenzoic acid and a wide range of commercially available amines and aldehydes. The key heterocyclization step is achieved unde r mild conditions and was found to be general for a large number of di verse inputs. (C) 1998 Elsevier Science Ltd. All rights reserved.