A NEW AND SIMPLE LEGO SYSTEM FOR THE SYNTHESIS OF 2,6-OLIGOPYRIDINES

Authors
PABST GR SAUER J
Citation
Gr. Pabst et J. Sauer, A NEW AND SIMPLE LEGO SYSTEM FOR THE SYNTHESIS OF 2,6-OLIGOPYRIDINES, Tetrahedron letters, 39(37), 1998, pp. 6687-6690
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
37
Year of publication
1998
Pages
6687 - 6690
Database
ISI
SICI code
0040-4039(1998)39:37<6687:ANASLS>2.0.ZU;2-0
Abstract
The condensation of alpha-arylglyoxals with carboxamidrazones 1 - 2 is the best method for the synthesis of aryl or hetaryl substituted 1,2, 4-triazines 3 - 4. These 1,2,4-triazines can be easily transformed to pyridines by [4+2] cycloaddition with bicyclo[2.2.1]hepta-2.5-diene fo llowed by [4+2] cycloreversions of nitrogen and cyclopentadiene. This reaction sequence offers a new, simple and general access to 2,6-oligo pyridines 8 - 11 (C) 1998 Elsevier Science Ltd. All rights reserved.