L-ALPHA-PHOSPHATIDYL-D-MYO-INOSITOL 3,5-BISPHOSPHATE - TOTAL SYNTHESIS OF A NEW INOSITOL PHOSPHOLIPID VIA MYOINOSITOL ORTHOACETATE

Authors
RILEY AM POTTER BVL
Citation
Am. Riley et Bvl. Potter, L-ALPHA-PHOSPHATIDYL-D-MYO-INOSITOL 3,5-BISPHOSPHATE - TOTAL SYNTHESIS OF A NEW INOSITOL PHOSPHOLIPID VIA MYOINOSITOL ORTHOACETATE, Tetrahedron letters, 39(37), 1998, pp. 6769-6772
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
37
Year of publication
1998
Pages
6769 - 6772
Database
ISI
SICI code
0040-4039(1998)39:37<6769:L3-TS>2.0.ZU;2-L
Abstract
The synthesis from myo-inositol of a newly-discovered inositol phospho lipid, phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P-2], is desc ribed. The synthetic strategy, employing inter alia, a trimethylalumin ium-mediated regioselective cleavage of a protected inyo-inositol orth oacetate followed by an optical resolution using (R)-(-)-5-oxo-2-tetra hydrofurancarboxylate esters, allows rapid access to dipalmitoyl PtdIn s(3,5)P-2. (C) 1998 Elsevier Science Ltd. All rights reserved.