THE USE OF F-18! 4-FLUOROBENZYL IODIDE (FBI) IN PET RADIOTRACER SYNTHESIS - MODEL ALKYLATION STUDIES AND ITS APPLICATION IN THE DESIGN OF DOPAMINE-D(1) AND DOPAMINE-D(2) RECEPTOR-BASED IMAGING AGENTS

Authors
MACH RH ELDER ST MORTON TE NOWAK PA EVORA PH SCRIPKO JG LUEDTKE RR UNSWORTH CD FILTZ T RAO AV MOLINOFF PB EHRENKAUFER RLE
Citation
Rh. Mach et al., THE USE OF F-18! 4-FLUOROBENZYL IODIDE (FBI) IN PET RADIOTRACER SYNTHESIS - MODEL ALKYLATION STUDIES AND ITS APPLICATION IN THE DESIGN OF DOPAMINE-D(1) AND DOPAMINE-D(2) RECEPTOR-BASED IMAGING AGENTS, Nuclear medicine and biology, 20(6), 1993, pp. 777-794
Citations number
56
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Nuclear medicine and biology
ISSN journal
09698051 → ACNP
Volume
20
Issue
6
Year of publication
1993
Pages
777 - 794
Database
ISI
SICI code
0969-8051(1993)20:6<777:TUO4I>2.0.ZU;2-4
Abstract
F-18!4-Fluorobenzyl iodide (F-18!FBI) was prepared, and a series of model alkylation studies were conducted to determine its chemical reac tivity toward nitrogen and sulfur nucleophiles of varying nucleophilic ities. F-18!FBI was found to react rapidly with secondary amines and anilines to give the corresponding N-F-18!4-fluorobenzyl analogue in high yield. Amides and thiol groups required the use of a base catalys t. The utility of F-18!FBI was documented by investigation of dopamin e D1 and D2 receptor-based radiotracers.